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Heavy lifetime alcohol use significantly increases the risk of colorectal cancer, especially rectal cancer, according to a major U.S. screening trial. Consistent heavy drinking across adulthood was linked to a 91% higher risk, while former drinkers showed no elevated risk—suggesting that quitting alcohol may help reduce long-term cancer risk.

Reducing alcohol consumption in Australia by just one litre per person annually could significantly cut deaths from several major cancers, especially among older adults. A La Trobe University study using 70 years of national data links long‑term drinking to higher mortality from UADT, liver, colorectal, and breast cancers.

A new Dutch analysis suggests that reducing alcohol consumption by just two glasses per week from 2032 could prevent 11,529 cancer diagnoses by 2050. The estimate highlights the strong link between alcohol and at least seven cancer types, and strengthens the case for effective alcohol prevention policies.

Even a low daily intake of alcohol—just 9 g or around one standard drink—is linked to a 50% heightened risk of mouth (buccal mucosa) cancer in India, with the greatest risk associated with locally brewed alcohol. When combined with chewing tobacco, it likely accounts for 62% of all such cases.